Vinyl chloride Toxicological overview

 Vinyl chloride is readily and rapidly absorbed via inhalation, ingestion and through the skin  At room temperature vinyl chloride is a gas, so inhalation is the major route exposure  Following absorption, it is distributed through the body, with the highest concentrations found in the liver and kidneys, followed by the lungs and spleen  Vinyl chloride is mainly metabolised in the liver into reactive metabolites  Vinyl chloride is mainly excreted in the urine as thiodiglycolic acid